Deflazacort: therapeutic index, relative potency and equivalent doses versus other corticosteroids

Moderate dose inhaled corticosteroids plus salmeterol versus higher doses of inhaled corticosteroids in symptomatic asthma.

BACKGROUND There is uncertainty as to the dose of inhaled corticosteroids (ICS) at which to start concomitant long acting beta agonist (LABA) treatment in patients with asthma not adequately controlled by ICS alone. METHODS A meta-analysis was carried out of randomised, double blind clinical trials that compared the efficacy of adding salmeterol to moderate doses of ICS (fluticasone propionat...

The Relative Significance of Graded Immunizing and Challenge Doses in Measuring the Potency of Vaccines

A study of the effect of graded immunizing doses of typhoid vaccine and graded challenge doses of S. typhosa in 5 per cent mucin on the degree of gradation of response (survival or death) elicited in successive groups of mice is reported. In the range of doses employed the effect of graded immunizing doses was markedly greater than was the effect of graded challenge doses. Statistically the dif...

Once-daily versus more frequent use of same potency topical corticosteroids for atopic eczema

A systematic review of long-acting β2-agonists versus higher doses of inhaled corticosteroids in asthma.

OBJECTIVE To compare the efficacy of inhaled corticosteroids (ICS) plus long-acting β2 agonist (LABA) versus higher doses of ICS in children/adolescents with uncontrolled persistent asthma. METHODS Randomized, prospective, controlled trials published January 1996 to January 2012 with a minimum of 4 weeks of LABA+ICS versus higher doses of ICS were retrieved through Medline, Embase, Central, a...

A Systematic Review of Long-Acting b2-Agonists Versus Higher Doses of Inhaled Corticosteroids in Asthma

OBJECTIVE: To compare the efficacy of inhaled corticosteroids (ICS) plus long-acting b2 agonist (LABA) versus higher doses of ICS in children/adolescents with uncontrolled persistent asthma. METHODS: Randomized, prospective, controlled trials published January 1996 to January 2012 with a minimum of 4 weeks of LABA +ICS versus higher doses of ICS were retrieved through Medline, Embase, Central, ...